Smallpox
A severe variola virus disease eradicated worldwide; no naturally occurring cases have occurred since 1977.
Symptoms and what to notice
Historically caused high fever, severe aches, vomiting, and a deep, progressive pustular rash.
How long can it last?
Historically, illness developed over several weeks.
How serious is Smallpox?
Was often fatal and could cause blindness and permanent scarring. Any suspected case is a public-health emergency.
Treatment and management
National response plans include isolation, specialist care, antivirals, vaccination, and close-contact management.
Is there a vaccine—and who should receive it?
Smallpox vaccination is not routine. It is reserved for certain laboratory/response personnel and would be deployed under public-health direction after an emergency.
Official U.S. guidance
Read the current CDC guidance for Smallpox →
Cost: Patient cost varies by insurance, provider, location, and eligibility. Many recommended vaccines are covered with no out-of-pocket cost under qualifying plans, and eligible children may receive vaccines through the Vaccines for Children program. CDC price lists are purchasing benchmarks—not guaranteed patient prices. CDC price context.